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Apixaban spc

Eliquis 5 mg film-coated tablets - Summary of Product

In the apixaban vs warfarin study the incidence of ISTH major gastrointestinal bleeds (including upper GI, lower GI, and rectal bleeding) with apixaban was 0.76%/year. The incidence of ISTH major intraocular bleeding with apixaban was 0.18%/year. 9. DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION . Date of first authorisation:- 18 May 201

APIXABAN (APIXABANUM) ATC skupina: B01AF02: Název ATC skupiny: APIXABAN : Informace o registraci. Registrační číslo: EU/1/11/691/011: Registrační procedura: registrace centralizovaným postupem Společenství (s vyjimkou orphans) Stav registrace: R - registrovaný léčivý přípravek.. Eliquis (apixaban) EMA/416082/2018 Page 2/3 they move to another part of the body such as the lungs. Similarly, patients with atrial fibrillation are at high risk of clots forming in the heart, which can reach the brain where they can cause a stroke. The active substance in Eliquis, apixaban, is a 'factor Xa inhibitor' Apixaban [Eliquis® ] - DO NOT DOSE REDUCE unless instructed by the Summary of Product Characteristics (SPC). Dose reductions are likely to increase the risk of a thrombotic event as the medication will be subtherapeutic. Seek advice if considering a dose reductio apixaban -SPC Výkony se středním a vysokým rizikem krvácení: přerušit léčbu 48 hodin před výkonem Výkony s malým rizikem krvácení: přerušit léčbu 24 hodin před výkonem Znovu zahájit léčbu jakmile to dovolí klinická situace SPC - Souhrn údajů o přípravku: eliquis-epar-product-information_cs.pdf: NR - Rozhodnutí o registraci: PIL - Příbalová informace: eliquis-epar-product-information_cs.pdf: PAR - Veřejná zpráva o hodnocení Text na obalu: eliquis-epar-product-information_cs.pdf: Braillovo písmo: Schváleno - text na obalu odpovídá zákonným.

• jestliže jste alergický(á) na apixaban nebo na kteroukoli další složku tohoto přípravku (uvedenou v bodě 6), • jestliže příliš krvácíte, • jestliže máte onemocnění některého orgánu, které zvyšuje riziko závažného krvácení (jako aktivní nebo nedávný vřed žaludku nebo střeva, nedávné mozkové krvácení) APIXA : Apixaban, an oral anticoagulant that directly inhibits factor Xa, has been approved by the FDA for prophylaxis of thrombosis in atrial fibrillation and surgical patients and treatment of venous thromboembolism (VTE). Unlike warfarin, it does not require routine therapeutic monitoring. However, in selected clinical situations, measurement of drug level would be useful (eg, renal.

Eliquis 5mg film coated tablets SPC Bristol-Myers

  1. 3.0 Apixaban 3.1 Indications 3.2 Contra-indications 3.3 Initiation 3.4 Dosing 3.5 Monitoring 3.6 Counselling 3.7 Adverse effects 3.8 Discharge 3.9 Management of adverse effects 3.10 Surgery 3.11 Discontinuation of therapy.
  2. g in.
  3. zkušenosti, a proto se apixaban nedoporučuje (viz body 4.4 a 5.2). Porucha funkce jater Přípravek Eliquis je kontraindikován u pacientů s jaterním onemocněním spojeným s koagulopatií a klinicky zjevným rizikem krvácení (viz bod 4.3). Přípravek se nedoporučuje podávat pacientům s těžkou poruchou funkce jater (viz body 4.4 a.

Apixaban (Eliquis ®) is an option for the prevention of stroke and systemic embolism in non-valvular atrial fibrillation in accordance with its licensed indication; with one or more of the following risk factors How is this medicine (Apixaban) best taken? Use apixaban as ordered by your doctor. Read all information given to you. Follow all instructions closely. Take with or without food. If you have trouble swallowing apixaban, it can be crushed and mixed in water, apple juice, or applesauce. If you crush and mix apixaban, take it within 4 hours of mixing (apixaban) 2.5 mg & 5 mg Film-coated Tablets Prescribing Information . Consult Summary of Product Characteristics (SmPC) before prescribing . PRESENTATION: Film-coated tablets; 5 mg and 2.5 mg apixaban. INDICATION: Prevention of stroke and systemic embolism in adults with non The manufactures summary of product characteristics noted that clarithromycin (500 mg, twice a day), an inhibitor of P-gp and a strong inhibitor of CYP3A4, led to a 1.6-fold and 1.3-fold increase in mean apixaban AUC and Cmax respectively

Apixaban is a type of medicine known as an anticoagulant. It makes your blood clot more slowly. Blood clotting (thickening) is a complicated process involving substances called clotting factors. Clotting factors are made by the liver and help stop bleeding The anticoagulant effect of apixaban can be expected to persist for at least 24 hours after the last dose (i.e., about two half-lives). An agent to reverse the anti-factor Xa activity of apixaban is available. Please visit www.andexxa.com for more information on availability of a reversal agent Apixaban is suitable for adults aged 18 years and over. Most adults can take it, but it may not be suitable if you: currently have any severe bleeding rivaroxaban a apixaban je dle SPC možné použít ještě do hodnoty CrCl 15 ml/min. Závěrečné poznámky. Je prosazováno, aby Doporučení pro bezpečnou léčbu s NOAC v úpravě dle místních podmínek nebo speciálního zaměření (anesteziologie), byla k disposici pro lékaře a jin ELIQUIS (apixaban): Simple dosing for stroke prevention in NVAF, with or without food In the ARISTOTLE clinical trial, the majority of patients were on 5 mg BD (95.3%, n = 8,692/9,120) 2 * Liver function testing should be performed prior to initiating ELIQUIS

ELIQUIS, 5MG TBL FLM 168, Státní ústav pro kontrolu léči

  1. APIXABAN. Consult SPC for detailed guidance before prescribing. Apixaban is an anti-Xa inhibitor. available as 2.5mg and 5mg tablets. Indications . Apixaban is indicated for. Stroke prevention in non-valvular atrial fibrillation ; Prevention of thromboembolism post total knee replacement (TKR) and post total hip replacement (THR) Treatment of.
  2. Apixaban can be taken either with or without food. Swallow the tablet with a drink of water. If you have difficulty swallowing the tablet whole, you can crush the tablet and then mix it with 30 ml (two tablespoons) of water or apple juice, or alternatively, add it to some apple purée
  3. Switching between apixaban and anticoagulants other than warfarin: Discontinue one being taken, and begin the other at the next scheduled dose. Switching from warfarin to apixaban: Discontinue warfarin and initiate apixaban when INR . 2.0 Switching from apixaban to warfari
  4. Apixaban is an oral, direct factor Xa inhibitor that inhibits both free and clot-bound factor Xa, and has been approved for clinical use in several thromboembolic disorders, including reduction of stroke risk in non-valvular atrial fibrillation, thromboprophylaxis following hip or knee replacement surgery, the treatment of deep vein thrombosis or pulmonary embolism, and prevention of recurrent.
Business Development | Bluepharma

SPC for more detail) Apixaban has the following interaction information: Anticoagulants increased risk of haemorrhage when apixaban given with other anticoagulants (avoid concomitant use except when switching with other anticoagulants or using heparin to maintain catheter patency Apixaban (Eliquis®) for stroke prevention in atrial fibrillation 1. Baseline assessment prior to initiation of apixaban (Eliquis®) (Refer to BNF/SPC for a full up-to-date list of interactions) Drug Interactions with apixaban HIV Protease Inhibitors e.g. ritonavir and systemi Purpose: Crushed tablet and solution formulations of apixaban administered orally or via a nasogastric tube (NGT) may be useful in patients unable to swallow solid dose formulations. It is important to understand whether new formulations and/or methods of administration impact apixaban bioavailability and pharmacokinetic properties Active ingredient: apixaban. Inactive ingredients: anhydrous lactose, microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, and magnesium stearate. The film coating contain

Apixaban [Eliquis® Specialist Advised Drug Checklist

Apixaban was superior to standard oral anticoagulation at preventing stroke or systemic embolism in one large, double-blind study in patients with atrial fibrillation and at least one risk factor for stroke. It was also associated with a significant reduction in risk of major bleeding Apixaban can be given as oral solution or via nasogastric or gastric tube on an empty stomach. Food impairs bioavailability of the crushed tablets. There are insufficient data to recommend enteral administration of edoxaban and the package insert recommends against altering tablets Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020. LPD Title: Apixaban tablet LPD Date: 10 May 2016 Country: Vietnam Reference UK SPC date: Jan 2016 ELIQUIS® Apixaban Rx CANH BAO DAC BIET: Thuoc ban theo don. Doc ky hirffng dan sir dung truo'c khi dung. Khong dung qua lieu chi djnh. Tham khao y kien bac si neu co bat ky tac dung khong mong muon nao. Neu can them thong tin, xin hoi y kien bac si Přípravky obsahující apixaban, rivaroxaban, fondaparinux, danaparoid natrium a PF4. Interference: Chylozita, ikterita, hemolýza silně ovlivňují stanovení. předností je, že na rozdíl od nepřímých inhibitorů (frakcionované hepariny, pentasacharidy) není k účinku potřeba vazby na antitrombin

Patients on apixaban. I am a patient based in the UK who has been prescribed apixaban . CONTINUE. Members of the public. I am a member of the general public based in the UK . CONTINUE *This promotional site is only intended for healthcare professionals seeking information on ELIQUIS (apixaban) in the UK Apixaban oral tablet is a prescription drug used to treat and prevent blood clots such as deep vein thrombosis (DVT) and pulmonary embolism (PE). It also helps decrease risk of stroke in atrial.

Because of high plasma protein binding, apixaban is not expected to be dialyzable [see Clinical Pharmacology (12.3)]. Protamine sulfate and vitamin K would not be expected to affect the anticoagulant activity of apixaban. There is no experience with antifibrinolytic agents (tranexamic acid, aminocaproic acid) in individuals receiving apixaban NOAC New oral anticoagulant (dabigatran, rivaroxaban, or apixaban) SPC Summary of Product Characteristics TTR Time in therapeutic range U&Es Urea and electrolytes WSCCG NHS West Suffolk Clinical Commissioning Group Authors Linda Lord - Head of Medicines Management, WSCCG Emma Harris - Medicines Management Pharmacist, WSCCG Contributor Apixaban (Eliquis ) and rivaroxaban (Xarelto ) are direct, highly selective, orally active inhibitors of activated factor X (factor Xa). All 3 new oral anticoagulants are licensed for Apixaban to warfarin: Start warfarin and stop apixaban 3 days later, or stop apixaban, begin a parenteral anticoagulant (UFH or LMWH) and warfarin at the time apixaban would have been due, and then stop LMWH or UFH when INR therapeutic. LMWH/fonda to apixaban: Stop LMWH/fonda and start apixaban 0-2 hours before next LMWH/fonda dose is due

Raskt innsettende effekt | ELIQUIS (apixaban)

APIXA - Clinical: Apixaban, Anti-Xa, Plasm

Eliquis European Medicines Agenc

Apixaban (also known as Eliquis®) is a medicine that helps prevent the blood from clotting. It is an option for patients with deep vein thrombosis/pulmonary embolism. Sometimes harmful blood clots can form in the blood vessels of your legs, lungs, brain or heart, and cause a blockage If you are a patient prescribed apixaban based in the US, please CLICK HERE. Leaving hcp.eliquis.com X. You are about to leave the Bristol-Myers Squibb and Pfizer hcp.eliquis.com site. You are being redirected to a Bristol-Myers Squibb corporate site..

LPD Title: Apixaban tablet LPD Date: 10 May 2016 Country: Vietnam Reference UK SPC date: Jan 2016 ELIQUIS® Apixaban Rx CANH BAO DAC BIET: Thuoc ban theo dun. Doc ky hirong dan su dung trirtrc khi dung. Khong dung qua lieu chi dinh. Tham khao y kien bac si neu co bat ky tac dung khong mong muon nao. Neu can them thong tin, xin hoi y kien bac si Evidence-based recommendations on apixaban (Eliquis) for treating and preventing recurrent deep vein thrombosis or pulmonary embolism in adults.. Please see the NICE guideline on venous thromboembolism for further guidance on using this drug.. Is this guidance up to date? We reviewed the evidence in November 2019.We found nothing new that affects the recommendations in this guidance Eliquis (apixaban) is an anticoagulant (blood thinner) used for reducing the risk of blood clots in the heart and strokes in patients with atrial fibrillation who have no problems with their heart valves (nonvalvular atrial fibrillation).Eliquis is also used to treat and prevent deep vein thrombosis and pulmonary embolism (PE) in patients who have undergone hip or knee replacement surgery

APIXABAN Drug BNF content published by NIC

Apixaban Warfarin CMP/SE 1,27 1,60 Ischemická CMP 1,54 1,50 Hemoragická CMP 0,24 0,47 Intrakraniální krvácení 0,33 0,80 -0,5 0 0,5 1,0 1,5 0,011 0,87 <0,001 <0,001 Apixaban vs warfarin HR (95% CI) P hodnota Lepší warfarin Lepší apixaban RRR - 21% RRR - 49% RRR - 58% RRR +2% Definice závažného krvácení ve studiích Uses. Apixaban is used to prevent serious blood clots from forming due to a certain irregular heartbeat (atrial fibrillation) or after hip/knee replacement surgery.With atrial fibrillation, part. SPC Active Ingredients Company; Eliquis 2.5 mg film-coated tablets -10/08/20: 10/08/20: apixaban : Bristol-Myers Squibb-Pfizer : Eliquis 5mg film coated tablets -10/08/20: 10/08/20: apixaban : Bristol-Myers Squibb-Pfize

Dosering av Eliquis ved atrieflimmer (NVAF)| ELIQUIS

See edoxaban SPC for further details. If you have a patient already on a lower dose due to either weight or renal function, there is no further dose reduction required in relation to the above interacting drugs therefore if a patient is already on 30mg then do not reduce to 15mg 2 Dosing o The recommended dose of apixaban for management of acute DVT or PE is 10mg TWICE daily for the first 7 days, then 5mg TWICE daily thereafter.For patients with severe renal impairment (CrCl 15- 29 ml/min), apixaban 5mg twice daily should be used with caution • Apixaban should be restarted as soon as possible after the invasive procedure or surgical intervention, provided the clinical situation allows and adequate haemostasis has been established • Refer to SPC and BNF for contraindications and further information

Apixaban: Indications, Side Effects, Warnings - Drugs

Apixaban (apx), with a trade name of Eliquis, is a highly selective and efficacious inhibitor of blood coagulation factor Xa. Apixaban has poor solubility in water (0.028 mg/mL at 24 °C) and a relatively low oral bioavailability (about 50% for a single 10 mg dose). The purpose of this study is to improve the solubility and consequently the oral bioavailability of apixaban via a cocrystal. A. Warfarin, apixaban (Eliquis) and dabigatran (Pradaxa) should be taken with water. Rivaroxaban (Xarelto) is normally taken with food. Depending on your dose, you may need to take more than one tablet or capsule at a time

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Scenario: Apixaban Management Anticoagulation - oral

Apixaban: a blood-thinning medicine to treat and prevent

Apixaban offers many potential advantages over warfarin e.g. relatively few interactions and no need for coagulation monitoring, although bleeding rates are similar. In common with other novel anticoagulants, there is no currently licensed or approved antidote. Apixaban may accumulate in renal and hepatic failure the agreed transfer of care guidance is followed. If apixaban is prescribed for unlicensed indications outside the scope of local guidance, prescribing responsibility will remain with the initiating clinician. Contraindications (for full details - see BNF orSPC) Cautions (for full details - see BNF or SPC apixaban, and rivaroxaban, and the direct thrombin in-hibitor, dabigatran etexilate, are in advanced stages of evaluation for this indication [9-13] (Table 2). In this ar-ticle, we review the pharmacological and clinical data for the use of apixaban in ACS. Pharmacology Apixaban (Bristol-Myers Squibb, New York, NY) is a

Oral Anticoagulant Rx ELIQUIS® (apixaban) Safety Inf

Apixaban should be started instead of the next scheduled administration of dalteparin (if a patient has received 7 days or more of dalteparin, then apixaban should be started at 5mg bd (as for day 8 onwards) and if a patient has received less than 7 days apixaban should be started at 10mg bd for 7 days then reduced to 5mg bd) • Rivaroxaban and apixaban have a peak effect 1-3 hours after oral intake and if PT/INR and aPTT testing is done within this time period, this can lead to elevated PT/INR and aPTT. For example, soon after oral intake, INR may be elevated to 1.7-2.5, the aPT

Eliquis tablets (apixaban): uses, dose and side effect

After 2 days of co-administration obtain INR prior to next dose of apixaban. Continue co-administration of apixaban and warfarin until INR is greater than or equal to 2·0. Stop apixaban. Start edoxaban at the time the next dose of apixaban would have been due. Stop apixaban. Start rivaroxaban when the next dose of apixaban would have been due (SPC), ale i s dalšími postupy, jako je převod mezi jednotlivými antikoagulancii, nebo s laboratorní The internists can indicate the new oral anticoagulants (rivaroxaban, apixaban and dabigatran) in the treatment of their patients now. We present an overview of their effects and several advice for possible monitoring in practice The Renal Drug Database. The Renal Drug Handbook is now available in database format. Access monograph information through desktop, laptop or mobile devices, with this new, easy-to-use, frequently-updated online platform

Apixaban Dosing For NVAF Patients Eliquis U

Apixaban, sold under the brand name Eliquis among others, is an anticoagulant medication used to treat and prevent blood clots and to prevent stroke in people with nonvalvular atrial fibrillation. Specifically it is used to prevent blood clots following hip or knee replacement and in those with a history of prior clots. It is used as an alternative to warfarin and does not require monitoring. Apixaban is metabolized mainly via CYP3A4 with minor contributions from CYP1A2, 2C8, 2C9, 2C19, and 2J2. O-demethylation and hydroxylation at the 3-oxopiperidinyl moiety are the major sites of biotransformation. Unchanged apixaban is the major drug-related component in human plasma; there are no active circulating metabolites. Eliminatio Summary of Product Characteristics (SPC); Apixaban - Eliquis®, Bristol-Myers Squibb-Pfizer, electronic Medicines Compendium, Jul 2014. Summary of Product Characteristics (SPC); Dabigatran etexilate®, Boehringer Ingelheim Limited, electronic Medicines Compendium, Dec 201 Eliquis preparatomtale (SPC), pkt. 5.2; Agnelli G, Buller HR, Cohen A, et al. Oral apixaban for the treatment of acute venous thromboembolism. New Engl J Med 2013;369:799-808; Raskob GE, Gallus AS, Sanders P et al. Early time courses of recurrent thromboembolism and bleeding during apixaban or enoxaparin/warfarin therapy. Thromb Haemost 2016; 11 Among AF patients, 141 (51.8%) were treated with apixaban and 131 (48.2%) with vitamin K antagonists. Early safety endpoints at 30 days were lower among apixaban-treated patients versus vitamin K antagonist-treated patients (13.5% vs. 30.5%, p 0.01). Groups were compared using Kaplan-Meier estimates

apixaban - General Practice Noteboo

This study will investigate the bioavailability of apixaban administered as crushed tablets suspended in water and as crushed tablets mixed with applesauce compared with that of whole tablets. The study results may allow enhancement of the apixaban label to include alternative methods of apixaban administration, which may be of benefit to. Apixaban versus warfarin in patients with atrial fibrillation according to prior warfarin use: results from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial. Am Heart J. 2013 Sep;166(3):549-58. doi: 10.1016/j.ahj.2013.05.016. Epub 2013 Jul 25 SPC; Be Well™ Account Apixaban may need to be stopped temporarily before dental or surgical procedures to reduce your risk of bleeding heavily during or after the procedure. Pregnancy: The safety and effectiveness of apixaban have not been established for pregnant women. Apixaban is not recommended during pregnancy Apixaban. In the AMPLIFY RCT of apixaban 5 mg twice daily versus enoxaparin followed by a warfarin target INR of 2.5, relevant baseline risk factors for recurrent VTE included known thrombophilia: 74 (2.85%) patients in the apixaban arm, and 59 (2.2%) patients in the enoxaparin followed by warfarin arm

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